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GRACE BR SIMANUNGKALIT Pengarang dr. Edwin Anto Pakpahan, Sp.P(K) Dosen Pembimbing 1 dr. Juliyanti Tarigan, M.Ked(DV) Sp.DV, FINS-DV Dosen Pembimbing 2 dr. Maestro B.U. Simanjuntak, M.Kes. Penguji 1 Assoc. Prof. Dr. dr. Endy Juli Anto, MKT., AIFO-K Penguji 2

ABSTRAK Latar Belakang: Penyakit Paru Obstruktif Kronik (PPOK) merupakan masalah kesehatan global yang semakin meningkat, ditandai dengan obstruksi jalan nafas yang buruk, bronkiolitis obstruktif kronik dan emfisema. Penyakit ini disebabkan oleh paparan asap rokok dalam jangka waktu lama serta udara yang tidak bersih. Tujuan Penelitian: Untuk mengetahui apakah terdapat hubungan kadar eosinofil dan neutrofil pada Penyakit Paru Obstruktif Kronik (PPOK) stabil. Metode Penelitian: Penelitian ini merupakan penelitian desain cross sectional. Hasil Penelitian : Pada analisis terdapat hubungan kadar eosinofil pada Penyakit Paru Obstruktif Kronik (PPOK) stabil dengan nilai p values 0,002; dan terdapat hubungan kadar neutrofil pada Penyakit Paru Obstruktif Kronik (PPOK) stabil dengan nilai p values 0,030 di RSU Grandmed Lubuk Pakam. Kesimpulan: Berdasarkan hasil penelitian terdapat hubungan kadar eosinofil dan neutrofil pada Penyakit Paru Obstruktif Kronik (PPOK) stabil di RSU Grandmed Lubuk Pakam. Kata Kunci: Penyakit Paru Obstruktif Kronik (PPOK), eosinofil, neutrofil i ABSTRACT Background: Chronic obstructive pulmonary disease (COPD) is an increasing global health problem, characterized by severe airway obstruction, chronic obstructive bronchiolitis and emphysema. This disease is caused by long-term exposure to cigarette smoke and unclean air. Research Objective: To determine whether there is a relationship between eosinophil and neutrophil levels in stable Chronic Obstructive Pulmonary Disease (COPD). Research Method: This research is a cross sectional design research. Research Results: In the analysis, there was a relationship between eosinophil levels in Chronic Obstructive Pulmonary Disease (COPD) which was stable with a p value of 0.002, and there was a relationship between neutrophil levels in Chronic Obstructive Pulmonary Disease (COPD) which was stable with a p value of 0.030 at RSU Grandmed Lubuk Pakam. Conclusion: Based on the research results, there is a stable relationship between eosinophil and neutrophil levels in Chronic Obstructive Pulmonary Disease (COPD) at RSU Grandmed Lubuk Pakam. Keywords: Chronic Obstructive Pulmonary Disease (COPD), eosinophils, neutrophils